{"id":1316,"date":"2025-12-15T09:18:28","date_gmt":"2025-12-15T09:18:28","guid":{"rendered":"https:\/\/crai.es\/?page_id=1316"},"modified":"2026-02-20T11:05:12","modified_gmt":"2026-02-20T11:05:12","slug":"neurophytome","status":"publish","type":"page","link":"https:\/\/crai.es\/en\/neurophytome\/","title":{"rendered":"NeuroPhytome – Interacciones entre plantas y cerebro"},"content":{"rendered":"
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Interacciones planta\u2013cerebro desde una perspectiva evolutiva<\/mark><\/p>\n\n\n\n

An Interdisciplinary Research Project<\/mark><\/p>\n<\/div><\/div>\n\n\n\n

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NeuroPhytome Project<\/mark><\/h2><\/div>\n\n\n\n
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NeuroPhytome is a project embedded within the research line Evolutionary Foundations of Human\u2013Plant Interaction under the HPCN Pillar of CRAI.\n\nNeuroPhytome addresses a central question: how long-term changes in agriculture, selection for yield and uniformity, and stress-minimization practices have reshaped the phytochemical architecture of plant-based foods, thereby altering the landscape of plant-derived regulatory signals to which human physiology is chronically exposed.<\/p>\n<\/div>\n<\/div><\/div>\n\n\n\n

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Hypothesis<\/h3><\/div>\n\n\n\n

NeuroPhytome is based on the premise that the human organism has historically been exposed to complex phytochemical landscapes derived from plant matrices cultivated under ecologically variable conditions.\n\nThese landscapes do not function as isolated pharmacological agents, but as low-intensity signalling environments that interact with conserved regulatory systems, including redox, metabolic, inflammatory, and epigenetic networks.\n\nThe progressive simplification of phytochemical diversity within contemporary agricultural systems may have reduced the structural richness of these regulatory signals, with potential implications for baseline regulatory tone across the lifespan.\n\nThe project does not propose direct causality or immediate clinical effects; rather, it advances the hypothesis that sustained changes in the phytochemical architecture of the dietary environment may influence long-term biological resilience and adaptive capacity.<\/p>\n<\/div><\/div>\n\n\n\n

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Vision<\/h3><\/div>

NeuroPhytome seeks to consolidate a scientific framework that enables plant-based foods to be understood as architectures of biological signaling, beyond their content of individual nutrients.
El proyecto busca posicionar el estudio de matrices fitoqu\u00edmicas complejas como una dimensi\u00f3n estrat\u00e9gica en la investigaci\u00f3n sobre regulaci\u00f3n biol\u00f3gica basal, envejecimiento funcional y resiliencia sist\u00e9mica.<\/p><\/div><\/div>\n\n\n\n

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From Molecular Profiles to Systemic Regulation<\/h3><\/div>

NeuroPhytome develops an integrated analytical pathway that connects the metabolomic characterisation of whole plant matrices with the study of conserved regulatory networks and their functional interpretation at the systemic level. The approach shifts the focus from individual compounds toward structural diversity, patterns of co-occurrence, and the matrix organisation of complex phytochemical networks. This perspective enables plant-based foods to be understood as architectures of biological signalling, capable of interacting with redox, metabolic, and inflammatory systems that sustain baseline regulatory balance. The result is a coherent interpretative framework linking phytochemical diversity to long-term functional stability.
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The scientific gap<\/h3><\/div>

Contemporary research reveals a significant disconnect:<\/p><\/div><\/div>\n\n\n\n

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<\/path><\/svg><\/span>There is extensive evidence demonstrating the activation of regulatory pathways through isolated compounds under acute experimental conditions.<\/span><\/div>\n\n\n\n
<\/path><\/svg><\/span>However, the impact of chronic exposure to whole phytochemical matrices at nutritionally realistic intake levels remains insufficiently characterised.<\/span><\/div>\n\n\n\n
<\/path><\/svg><\/span>Structural changes in phytochemical diversity resulting from modern agricultural practices are rarely examined in relation to baseline biological regulation.<\/span><\/div>\n\n\n\n
NeuroPhytome addresses this gap from an evolutionary and systems-level perspective, focusing on the architecture of the phytochemical landscape and its potential cumulative influence on regulatory balance.<\/span><\/div>\n<\/div><\/div>\n\n\n\n
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Methodological approach<\/h3><\/div>

The project integrates complementary disciplines to address complex biological questions:<\/p><\/div><\/div>\n\n\n\n

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<\/path><\/svg><\/span>Phytochemistry and metabolomics<\/strong> \u2013 characterization of compounds of plant origin<\/span><\/div>\n\n\n\n
<\/path><\/svg><\/span>Neurobiology and epigenetics<\/strong> \u2013 study of regulatory and signaling routes<\/span><\/div>\n\n\n\n
<\/path><\/svg><\/span>Evolutionary biology<\/strong> \u2013 contextualizaci\u00f3n en la historia evolutiva humana<\/span><\/div>\n\n\n\n
<\/path><\/svg><\/span>Computational analysis<\/strong> \u2013 data integration and pattern identification<\/span><\/div>\n\n\n\n
<\/path><\/svg><\/span>Systems Biology<\/strong> \u2013 interpretation of interactions beyond isolated effects<\/span><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n
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Scientific and social relevance<\/h3>\n\n\n\n

NeuroPhytome contributes to redefining food quality from a regulatory and structural perspective, focusing on the functional architecture of complex phytochemical matrices rather than solely on the presence of isolated nutrients. The project positions the institute at the interface of advanced plant science, systemic biological regulation, functional ageing, and adaptive resilience.\n\nIn the medium and long term, this approach may inform the development of functional nutrition strategies based on whole matrices, the optimisation of cultivars with structurally more diverse and coherent phytochemical profiles, and new research directions in ageing and neurodegenerative processes from a preventive perspective. Without presupposing specific clinical applications, the project establishes solid conceptual and mechanistic foundations for future personalised strategies grounded in complex biochemical environments.<\/p>\n\n\n\n

Expected results<\/h3>\n\n\n\n

NeuroPhytome will generate comparative maps of phytochemical diversity in plant matrices and develop interpretative models linking plant metabolic architecture to human baseline regulation. It will also produce mechanistic evidence on the interaction between complex phytochemical landscapes and key regulatory systems, including redox, metabolic, and inflammatory networks.\n\nThese advances will help consolidate a robust conceptual framework for future research on systemic resilience and functional ageing, while providing a structured foundation for transfer toward agro-functional and biomedical innovation.<\/p>\n\n\n\n

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Team and collaborations<\/h3>\n\n\n\n

The project is coordinated by the Centro Rausenbach de An\u00e1lisis e Investigaci\u00f3n (CRAI) and is structured within the Neurobot\u00e1nica platform.\n\nIt is conceived as an open international network fostering collaboration with universities, research centres, and strategic partners interested in the interface between plants, biological regulation, and human evolution.<\/p>\n\n\n\n

Collaboration<\/h3><\/div>\n\n\n\n

We invite academic institutions, foundations, and strategic partners to establish contact in order to explore scientific collaborations, joint project development, and knowledge transfer in the field of complex phytochemical matrices and systemic regulation.\n\nNeuroPhytome represents a strategic commitment to advancing a deeper understanding of the link between plant biodiversity and human biological stability.<\/p>\n\n\n\n

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Contact<\/div><\/a><\/div><\/div>\n\n\n\n
Report<\/div><\/a><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

NeuroPhytome Project NeuroPhytome es un proyecto enmarcado en la l\u00ednea Bases evolutivas de la interacci\u00f3n humano\u2013planta del Pilar HPCN del CRAI. NeuroPhytome aborda una pregunta central: c\u00f3mo los cambios a largo plazo en agricultura, selecci\u00f3n por rendimiento y uniformidad, y pr\u00e1cticas de minimizaci\u00f3n de estr\u00e9s han reconfigurado la arquitectura fitoqu\u00edmica de los alimentos vegetales, alterando […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"enabled","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1316","page","type-page","status-publish","hentry"],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"trp-custom-language-flag":false},"uagb_author_info":{"display_name":"draus@raus-partner.com","author_link":"https:\/\/crai.es\/en\/author\/drausraus-partner-com\/"},"uagb_comment_info":0,"uagb_excerpt":"NeuroPhytome Project NeuroPhytome es un proyecto enmarcado en la l\u00ednea Bases evolutivas de la interacci\u00f3n humano\u2013planta del Pilar HPCN del CRAI. NeuroPhytome aborda una pregunta central: c\u00f3mo los cambios a largo plazo en agricultura, selecci\u00f3n por rendimiento y uniformidad, y pr\u00e1cticas de minimizaci\u00f3n de estr\u00e9s han reconfigurado la arquitectura fitoqu\u00edmica de los alimentos vegetales, alterando…","_links":{"self":[{"href":"https:\/\/crai.es\/en\/wp-json\/wp\/v2\/pages\/1316","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/crai.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/crai.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/crai.es\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/crai.es\/en\/wp-json\/wp\/v2\/comments?post=1316"}],"version-history":[{"count":70,"href":"https:\/\/crai.es\/en\/wp-json\/wp\/v2\/pages\/1316\/revisions"}],"predecessor-version":[{"id":1961,"href":"https:\/\/crai.es\/en\/wp-json\/wp\/v2\/pages\/1316\/revisions\/1961"}],"wp:attachment":[{"href":"https:\/\/crai.es\/en\/wp-json\/wp\/v2\/media?parent=1316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}